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Daniel David Cecchi
University of Victoria
Efficacy of Gold Nanoparticles for High Dose Rate Brachytherapy: An In Vitro and in vivo Study
Gold nanoparticles (GNPs) are promising radiosensitizing agents for high dose rate brachytherapy (HDR); however, complex treatment delivery for HDR has prohibited systematic evaluation of GNP-induced radiosensitization both in vitro and in vivo. Here, we use...
Poster Program · Therapy Physics
Gold Nanoparticle Targeting with Linear and Cyclic RGD Peptides for Radiotherapy Enhancement
Gold nanoparticles (GNPs) are candidate cancer cell radiosensitizers, they can be targeted with peptides containing the αvβ3 integrin binding domain RGD (arginine, glycine, aspartic acid). This integrin is overexpressed in many cancer cells. Peptide shape-bas...
Poster Program · Therapy Physics
Radiosensitizing Prostate Cancer Though the Simultaneous Administration of Gold Nanoparticles and Chemotherapeutics
Radiotherapy with a 6 MV linear accelerator is extensively employed in cancer treatment, particularly for targeting deep-seated tumors. In our work, we have focused on maximizing the dose that can be safely delivered to patients. Our primarygoal is to optimiz...
Poster Program · Therapy Physics
Evaluation of Synergistic Radiosensitization Using Gold Nanoparticles and paclitaxel for HDR Brachytherapy In 2D and 3D Prostate Cancer Models
To investigate the synergistic radiosensitization of gold nanoparticles (GNPs) and paclitaxel (PTX) in high dose-rate (HDR) brachytherapy for prostate cancer using 2D (monolayer) and 3D (spheroid) cell models. HDR is used as a localized boost following extern...
Proffered Program · Therapy Physics