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Author profile
Scott James Bright
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Metabolic Constraints Limit DNA Repair Following Radiation Exposure
Radiotherapy is central in lung cancer treatment, but many tumors are intrinsically radioresistant. A mechanism of radioresistance in lung cancer is mutations in the KEAP1 gene, which is present in a significant number (15-20%) of lung cancers. This leads to...
Poster Program · Therapy Physics
Polθ Inhibition Enhances Proton and Photon Radiotherapy By Increasing DNA Damage and Tumor Immunogenic Remodeling
To investigate the effects of combining proton and photon radiotherapy (RT) with a DNA polymerase theta inhibitor (Polθi) on DNA damage and promotion of tumor immunogenic remodeling.
Proffered Program · Therapy Physics
High-LET Alpha Particle Radiation Enhances the Potential of Tumor Cells to Activate an Anti-Tumor Immune Response Compared with Photons
High–linear energy transfer (LET) alpha-particle radiotherapy (RT) produces dense ionization tracks that generate complex DNA damage and may induce potent immunostimulatory signals. We compared alpha‑particle and photon RT across breast and pancreatic cancer...
Proffered Program · Therapy Physics
Biological Efficacy of Quasi-Monoenergetic Convergent Photons
Recent advancements in x-ray optics have led to the development of a Bragg-reflecting x-ray lens to converge radiation beams into a focus spot (Convergent Radiotherapy and Radiosurgery, CRnR, Haifa, Israel), generating quasi-monoenergetic x-rays (~60 keV) wit...
Proffered Program · Therapy Physics