Michael Vincent Lauria, PhD

To quantify the precision and accuracy of a five-dimensional computed tomography (5DCT) free-breathing simulation approach in a large clinical cohort.

A CT-simulation approach has been developed which images free breathing patients with lung tumors by generating a motion model that is a function of breathing amplitude and rate (5DCT). Of the >300 patients simulated with 5DCT, 13 have been simulated more tha...

MRI-guided lung SBRT has emerged as a novel treatment modality with the potential to enhance motion management and improve normal lung sparing. This retrospective study evaluates the extent of normal lung sparing achieved by real-time tracking and automatic g...

Online Adaptive Radiotherapy (oART) is resource and time-intensive, requiring dosimetrist, physicist, and physician involvement at each adapted fraction. The therapist-led adaptive workflow has been shown to reduce physician console-time. This study evaluates...

Functional avoidance radiotherapy requires accurate regional lung ventilation mapping. Jacobian-based free-breathing ventilation derived from deformable image registration (DIR) of 4DCT is established but susceptible to inaccuracies caused by errors in the di...

Endobronchial Valves (EBV) are one of the few treatment options for patients with moderate to severe emphysema. Eligibility is typically assessed from CT image data analysis including Emphysema Score (RA950) and Fissure Integrity Score (FIS). However not all...

Endobronchial Valves (EBV) are one of the few treatment options for patients with moderate to severe emphysema. Eligibility is typically assessed from CT image data analysis including Emphysema Score (Relative Area, RA950) and Fissure Integrity Score (FIS). H...

In investigating image-based lung ventilation, a fundamental question must be answered: is the measurement technique repeatable? Repeatability of ventilation imaging in PET and CT have been studied, but MRI is emerging. Crucial to deriving ventilation is the...

Standard Cone-Beam CT (CBCT) has limited utility in longitudinal lung tumor response assessment due to the presence of motion artifacts. Our proposed method of motion-compensated Simultaneous Algebraic Reconstruction Technique (mcSART) addresses these artifac...

4DCT is widely considered the standard for lung cancer radiation therapy treatment planning (TP) despite susceptibility to breathing-related motion artifacts that often render images unusable. Five-dimensional CT (5DCT), a model-based CT reconstruction method...

Recent advances in MRI could offer patients with benign lung disease whole-lung ventilation mapping that may serve as a surrogate for pathophysiological changes such as increased airway resistance and decreased lung compliance. Ventilation maps can be derived...

To test the feasibility of using lung hysteresis, or the difference in inhalation and exhalation motion trajectories, as a biomarker for mechanically affected lung.