Thomas R. Mazur

To perform comprehensive dosimetric validation of a commercially available independent Monte Carlo (MC)-based secondary dose calculation engine for clinical photon radiotherapy.

To develop and validate a novel isocentricity test using continuous axis motion and imaging during beam delivery to characterize three-dimensional isocenter walkout.

Online adaptive stereotactic body radiation therapy (SBRT) reduces organ at risk (OAR) dose for abdominal targets with highly variable anatomy but significantly increases treatment time and clinical workload. Adaptive workflows are routinely assigned to left...

This study investigates the feasibility of using two affordable optical surface–imaging technologies to generate detailed 3D maps of the treatment room and patient surface for detecting and mitigating potential collisions between the proton nozzle and the pat...

In the Phase I clinical trial (NCT05831579), we already performed the palliative spatially fractionated (GRID) proton therapy by using a collimating brass aperture. However, the existence of this brass aperture limits the flexibility of the high dose regions...

A novel, low-cost 3D surface scanning system was developed using a custom modification of the laser-profiling technique. Proof of concept was demonstrated through 3D simulation in Blender 3D software. A real-world prototype was then implemented using a consum...

To develop and validate a continuous two-dimensional output-factor (OF) model and to identify a measurement strategy that achieves accuracy and efficiency.

Online adaptive stereotactic body radiation therapy (SBRT) enables daily replanning to mitigate anatomic variation but increases treatment time and clinical workload. For left adrenal tumors, adaptive SBRT is frequently assigned due to the proximity of gastro...

Stereotactic arrhythmia radiotherapy (STAR) is an emerging treatment for ventricular tachycardia (VT) that uses radiation to modulate cardiac electrophysiology (EP) and reduce VT. Registering radiation planning 3D imaging to cardiac optical maps will enable o...

Large-animal studies of stereotactic arrhythmia radiotherapy (STAR) are faced with financial and logistical difficulties that limit widespread implementation. We developed a single-platform STAR porcine workflow on an O-ring linac utilizing manual end-exhalat...

Independent verification of IROC phantom credentialing results is valuable for institutional quality assurance and confidence in treatment planning system performance. This work aimed to verify the accuracy of a commercially available Monte Carlo (MC) dose al...

Proton plans are often homogenous with minimal hotspots, which may not be ideal for ablative stereotactic body radiation therapy (SBRT). A treatment planning approach for stereotactic body proton therapy (SBPT) is proposed to match the characteristics of phot...